Category Archives: Funding

EOL and PC Health Literacy R01/R21: Improving Outcomes in Serious, Advanced Illness

Types of studies may include innovative methods or approaches such as qualitative, mixed methods, observational, quasi-experimental, and experimental with focus on individual- and family-centered outcomes. It is strongly encouraged that the investigative teams be interdisciplinary and include nurse scientists and early stage investigators. Investigators are also encouraged to consider using existing palliative care research networks, such as the Palliative Care Research Cooperative Group, to carry out small, multi-site trials when appropriate.

For more information, visit:

https://grants.nih.gov/grants/guide/pa-files/PA-18-498.html

Changing policies impact NIH-funded studies involving human subjects

Message to NIH grant applicants/awardees, contractors, researchers and research administrators:

If you are conducting NIH-funded research that involves human subjects, or are considering applying to NIH for support of such research, we want to call your attention to important changes that may affect how you:

  • select the right NIH funding opportunity announcement
  • write the research strategy and human subjects sections of your application
  • comply with appropriate policies and regulations

First, familiarize yourself with the new PHS Human Subject and Clinical Trial Information form (for application due dates of January 25, 2018).  Learn about the new form here.

Second, review  the updated NIH definition of a clinical trialVisit the NIH webpage on the definition that includes case studies, FAQs and other resources that can help. Still unsure?  Contact your NIH program official or the scientific point of contact listed on the funding opportunity announcement to which you are applying.

Third, familiarize yourself with NIH policy changes related to enhancing stewardship of clinical trials.

Visit the new Clinical Trial Requirements for NIH Grantees and Contractors web page to bring together all the information you need to know.  Please review this information carefully.  Your attention to detail will be critical to ensuring successful funding of your clinical trial awards. 

Funding Opportunity Announcement (FOA) Webinar

National Cancer Institute: Healthcare Delivery Research Program

Funding Opportunity Announcement (FOA) Webinar:  

Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization

When: August 17, 2017 from 2:00 PM – 3:00 PM ET

Where: via WebEx (Register Here)

 Presenters: Dr. Erin Kent and Dr. Michelle Mollica

 

Summary: This webinar will provide an overview of the R01/R21 Funding Opportunity Announcement (FOA), Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization: Funding Opportunity (PAR-16-317/PAR-17-318).  This FOA invites applications for intervention research designed to support caregivers of adult cancer patients. Interventions are intended to provide caregivers with care training, promote coping skills, and ultimately help them manage care. Outcomes of such interventions are expected to (1) optimize patient health care utilization, (2) improve caregiver well-being, and (3) improve patient physical health and psychosocial outcomes.  The next receipt dates for all types of applications (new and resubmissions) are October 10, 2017; April 11, 2018; October 10, 2018; and April 11, 2019.  For more information about cancer caregiving research at NCI, please see our website.

PCRC Data Repository Expansion Grant Awards

The PCRC is pleased to announce two sets of awards.

Congratulations to the award winners of the PCRC grants to support the secondary analysis of existing data in the PCRC Data Repository.  The award winners are:

  • Kathleen M. Akgün, MD, MS, Yale School of Medicine, “Polypharmacy, statin use and 6-month dyspnea trajectories among older adults with serious, life-limiting diseases”
  • Angela Ghesquiere, PhD, MSW, Hunter College, City University of New York, “Exploring Psychological Symptoms as Moderators of Treatment Outcomes in the REST Study”
  • Yael Schenker, MD, MAS, University of Pittsburgh Montefiore Hospital, “Associations between polypharmacy, symptom burden, and quality of life in patients with advanced, life-limiting illness”

The PCRC is thrilled to support these investigators and learn of the findings from their secondary data analyses!

The PCRC also is expanding the PCRC Data Repository to include data from completed end-of-life and palliative care (EOLPC) studies that may have been conducted outside of the PCRC and without PCRC support. In late April, the PCRC published a funding announcement to support the data repository expansion initiative, and we are excited to announce that the PCRC Data Repository will be expanded to include study data from 11 EOLPC research projects! Once incorporated into the PCRC Data Repository, these data will be available to investigators for secondary data analyses. Please see the table below with information about the studies.

Datasets to be included in PCRC Data Repository: Award Winners
Principle Investigator Institution Study Title 
Benzi Kluger, MD, MS University of Colorado Does Outpatient Palliative Care Improve Patient-Centered Outcomes in Parkinson’s Disease
Margaret L. Campbell PhD, RN, FPCN Wayne State University Is death rattle a phenomenon that requires medical treatment?
Margaret L. Campbell PhD, RN, FPCN Wayne State University Rater intensity psychometrics for the Respiratory Distress Observation Scale
Margaret L. Campbell PhD, RN, FPCN Wayne State University Intensity cutpoints substantiation of the Respiratory Distress Observation Scale
Matthew R Baldwin, MD, MS Columbia University Frailty and Outcomes in Critical Illness Survivors-I (FOCIS-I)
Katherine R. Courtright, MD, MS University of Pennsylvania Choice Sets for Advance Directives
Stacy Fischer, MD University of Colorado Apoyo con Carino: (Support Through Caring) Improving Palliative Care Outcomes for Latinos with Advanced Cancer
Amber E. Barnato, MD, MPH, MS University of Pittsburgh Consumer Engagement
Amber E. Barnato, MD, MPH, MS University of Pittsburgh Organizational and Provider Norms of Life-sustaining Treatment Decision Making
Amber E. Barnato, MD, MPH, MS University of Pittsburgh Surrogate’s Heightened Emotions and Life support Decisions (SHEALD)
David Bekelman, MD, MPH VA Eastern Colorado Health Care System Collaborative Care to Alleviate Symptoms and Adjust to Illness in Heart Failure: Randomized Clinical Trial

The investigator and his/her analyst have been invited to attend a half-day workshop in Denver on Tuesday, June 13, 2017 to learn best practices for reproducible research and how to prepare data for inclusion in the repository. The training will be led by the current and former PCRC Data Informatics and Statistics Core (DISC) Directors, Dr. Katie Colborn and Dr. Diane Fairclough, respectively.  This workshop will be recorded (using Zoom), which can then be made available to other investigators wishing to utilize this valuable resource.  Stay tuned!

We encourage you to consider including any study data you may have for which you think additional secondary data analysis could be conducted and support those who need access to these datasets for preliminary data and/or grant proposal preparation.  Thank you in advance for considering adding your work to and conducting secondary analyses using the PCRC’s growing data repository!

For information about how to request data from the PCRC Data Repository, please complete this form on our website: http://palliativecareresearch.org/corescenters/disc/data-request-form/.  If you are considering adding study data to the PCRC Data Repository and would like more information, please contact Alexandra Tillman, PCRC Data Manager at [email protected]

Upcoming FOA from PCORI

A new, upcoming funding opportunity from the Patient-Centered Outcomes Research Institute (PCORI), entitled, “Symptom Management for Patients with Advanced Illness” will be announced on June 23, 2017.  This advanced notice, which can also be found on the PCORI website, is being provided to allow potential applicants additional time to identify collaborators, obtain stakeholder input on the research question, and develop responsive, high-quality proposals.

Please email [email protected] with any questions related to this funding announcement and please see below for further details about this upcoming funding opportunity.

FOA: Call for proposals for data to be included in the PCRC de-identified Data Repository

FUNDING OPPORTUNITY ANNOUNCEMENT: Call for proposals for data to be included in the PCRC de-identified Data Repository

Do you have data from a completed palliative care and/or end-of-life study that has unanswered questions?  Do you (or your protégés) wish that you could access existing data to conduct secondary analyses?  This opportunity is for you!

Resources are available through the PCRC to support inclusion of de-identified data in the PCRC de-identified Data Repository.

Please use this link to apply:  https://redcap.ucdenver.edu/surveys/?s=E3CLHPYTRW

Applications are due May 04, 2017.  Notifications of approval will be made by May 09, 2017.

Award: $2500 to prepare existing data set for inclusion in PCRC Repository and travel costs for PI and analyst to travel to Denver for ½ day training on Tuesday, June 13, 2017.

The PCRC is seeking applications for investigators to include their study data from palliative care and end-of-life studies in the PCRC de-identified Data Repository. We are especially interested in palliative care or end-of-life clinical trials or large observational studies. Ideally these studies are those that have been listed on clinicaltrials.gov, were IRB approved, have resulted in publication(s) in respected peer-reviewed journals and collected sufficient information to allow for secondary analyses. In order to include data in the repository, we will need to comply with your institution’s data use policies and procedures.   Depending on your institution, this may include obtaining official authorization to share the data with the PCRC Data Repository.

(Note: we cannot include Medicare/Medicaid claims data in the PCRC data repository.)

If your study is chosen, you and your data analyst will be invited to attend a ½ day workshop in Denver on Tuesday, June 13, 2017 to learn best practices for reproducible research and how to prepare your data for inclusion in the repository. Travel costs for you and your analyst will be covered by the PCRC. We will also award each recipient $2500 to offset costs associated with preparing the data before sending them to the repository.

Please click here for Frequently Asked Questions about this funding announcement.

Funding Opportunity: Support for Analysis of Secondary Data from the PCRC Data Repository


Applications due by May 2, 2017

Call for proposals for secondary analysis of data that currently exist in the PCRC Data Repository. The PCRC will grant two $50,000 awards to conduct a secondary analysis of repository data. Applications are due May 2, 2017 by 11:59 PM Mountain Time.  We strongly encourage you to look at the studies briefly described below, their data dictionaries (linked below) and to search the literature for papers that have been published from these studies previously. The PCRC Executive Committee and Data Informatics and Statistics Core (DISC) leadership will review the applications.  Notification of awards will be made by May 10, 2017.

Instructions for applicants:

  • Please fill out the online form: https://redcap.ucdenver.edu/surveys/?s=PNPKCRTCYL
  • Include a two-page summary of your research plan, aims, which data set you propose to use, budget and timeline (which can be uploaded with the electronic form linked above).

 

Data that currently exist in the PCRC data repository for analysis include:

 Statin Discontinuation

  • Multisite randomized trial of continuing versus discontinuing statins
  • Primary objective: to determine, among patients with life-limiting illness, if there is a difference in the proportion who die within 60 days after enrollment between patients for whom statins are discontinued versus patients who are maintained on the medication
  • Secondary objectives: overall survival, important CVD events, QOL, symptoms, performance status (Karnofsky), polypharmacy, satisfaction with care, costs
  • Total N: 381, 15 study sites

Best Supportive Care

  • Implementation of consensus-based standards for best supportive care in a clinical trial: a pilot study
  • Primary objective: using clinician behavior intervention checklist (BSC), test the feasibility of thorough documentation of BSC delivery
  • Secondary: estimate variance in the BSC checklist completion; assess provider satisfaction with BSC; evaluate differences in patient experience before and after introduction of the BSC checklist
  • Total N: 41 patients and 23 providers, 4 study sites

Reducing End-of-Life Symptoms with Touch (REST)

  • Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial
  • Ann Intern Med. 2008 Sep 16;149(6):369-79.
  • To evaluate the efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer
  • Repeated measures, six 30-minute massage or simple-touch sessions over 2 weeks
  • 380 adults with advanced cancer who were experiencing moderate-to-severe pain; 90% were enrolled in hospice
  • Total N: 380 patients, 15 hospice study sites

    Please click here for Frequently Asked Questions about this funding announcement.

AHRQ Announces Funding Opportunity for Developing Measures of Shared Decision Making

A new funding opportunity announcement from AHRQ solicits applications for research projects to develop, test and evaluate measures of shared decision making for research conducted in clinical settings. Shared decision making is a collaborative process in which patients and members of their clinical team make health care decisions that are informed by scientific evidence as well as patients’ values and preferences. Each project is expected to produce valid and reliable measures of shared decision making, along with instructions for implementing the measures and documentation on the development, testing and evaluation of the measures. The maximum cost for each project is $500,000 per year and $1.5 million for up to three years.